Regulation of heme oxygenase-1 gene by peptidoglycan involves the interaction of Elk-1 and C/EBP to increase expression
نویسندگان
چکیده
Chi-Chih Hung, Xiaoli Liu, Min-Young Kwon, Young-Ho Kang, Su Wol Chung, and Mark A. Perrella Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Newborn Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts; Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; and Department of Biological Sciences, College of Natural Sciences, University of Ulsan, Ulsan, South Korea
منابع مشابه
Regulation of heme oxygenase-1 gene by peptidoglycan involves the interaction of Elk-1 and C/EBPalpha to increase expression.
Heme oxygenase (HO)-1 is a cytoprotective enzyme with anti-inflammatory properties. HO-1 is induced during a systemic inflammatory response, and expression of HO-1 is beneficial during sepsis of a Gram-positive source. Systemic infection from Gram-positive organisms has emerged as an important cause of sepsis, with Staphylococcus aureus as a common etiology. An important mediator of Gram-positi...
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